5alpha-reductase - meaning and definition. What is 5alpha-reductase
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  3. 5alpha-reductase

What (who) is 5alpha-reductase - definition

CLASS OF MEDICATIONS WITH ANTIANDROGENIC EFFECTS USED PRIMARILY IN THE TREATMENT OF ENLARGED PROSTATE AND SCALP HAIR LOSS
5-alpha reductase inhibitors; 5-alpha reductase inhibitor; 5α-reductase inhibitor; 5a-reductase inhibitor; 5alpha-reductase inhibitor; 5alpha reductase inhibitor; 5a reductase inhibitor; 5A reductase inhibitor; 5A Reductase inhibitor; 5a Reductase inhibitor; 5a-Reductase inhibitor; 5alpha-Reductase inhibitor; 5alpha Reductase inhibitor; 5A-Reductase inhibitor; 5-alpha Reductase inhibitor; 5-alpha-Reductase inhibitor; 5 alpha-Reductase inhibitor; 5α reductase inhibitor; 5α Reductase inhibitor; 5 alpha Reductase inhibitor; 5 alpha reductase inhibitor; 5 alpha-reductase inhibitor; 5-a Reductase inhibitor; 5-a reductase inhibitor; 5 a reductase inhibitor; 5 a Reductase inhibitor; 5 a-Reductase inhibitor; 5 a-reductase inhibitor; 5-a-reductase inhibitor; 5-a-Reductase inhibitor; 5 α reductase inhibitor; 5 α Reductase inhibitor; 5 α-Reductase inhibitor; 5 α-reductase inhibitor; 5-α-reductase inhibitor; 5-α-Reductase inhibitor; 5-α Reductase inhibitor; 5-α reductase inhibitor; 5α-reductase inhibitors; 5-alpha-reductase inhibitor; 5ARI; 5α-Reductase inhibitors; DHT blockers; Dihydrotestosterone blockers; 5-alpha-Reductase Inhibitors

5α-Reductase         
  • A side view of 5AR with monoolein and NADPH in the hydrophobic pocket; a view of the 7 transmembrane domains from the top
  • doi = 10.1016/S0960-894X(98)00463-6 }}</ref>
  • doi = 10.2217/fon.10.149 }}</ref> which is why the mechanism shows the NADP+ getting attacked by the enolate formed rather than instant tautamerization occurring like in the case of 5α-reductase's work on testosterone. Finasteride does eventually get released from 5α-reductase enzyme-substrate complex which is why it is not considered a suicide inhibitor as the product eventually formed is dihydrofinasteride.
  • [[Steroidogenesis]], showing both actions of 5α-reductase at bottom center.
ENZYME FAMILY
5 alpha reductase; 5-alpha-reductase; 3-oxo-5a-steroid 4-dehydrogenase; 5 alpha-reductase; 5α-reductase; 3-oxo-5alpha-steroid 4-dehydrogenase; 5a-reductase; 5aReductase; Testosterone 5-alpha-Reductase; 5A-Reductase; 5α-reductase type 2; 5 a Reductase; 5-Alpha reductase; 5AR; EC 1.3.99.5; 3-oxo-5alpha-steroid:acceptor Delta4-oxidoreductase; 5-alpha reductase
5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism.
https://en.wikipedia.org/wiki/5α-Reductase
5α-Reductase inhibitor         
5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss. They are also sometimes used to treat excess hair growth in women and as a component of hormone therapy for transgender women.
https://en.wikipedia.org/wiki/5α-Reductase_inhibitor
DMSO reductase         
  • Active site ligand coordination of fully oxidized (Mo VI) DMSOR: two pyranopterindithiolene ligands, a serine-147 residue ligand, and an oxo-group ligand <ref name="REF2"/>
  • Proposed catalytic mechanism of DMSO reductase<ref name="REF2"/>
  • doi = 10.1006/jmbi.1996.0555 }}</ref>
  • doi = 10.1006/jmbi.1997.1513 }}</ref>
CLASS OF ENZYMES
Dimethyl sulfoxide reductase; Dimethyl sulphoxide reductase; Dimethylsulfoxide reductase; Dimethylsulphoxide reductase; EC 1.8.5.3; Dimethyl sulfide:menaquinone oxidoreductase
DMSO reductase is a molybdenum-containing enzyme that catalyzes reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). This enzyme serves as the terminal reductase under anaerobic conditions in some bacteria, with DMSO being the terminal electron acceptor.
https://en.wikipedia.org/wiki/DMSO_reductase

Wikipedia

5α-Reductase inhibitor

5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss. They are also sometimes used to treat excess hair growth in women and as a component of hormone therapy for transgender women.

These agents inhibit the enzyme 5α-reductase, which is involved in the metabolic transformations of a variety of endogenous steroids. 5-ARIs are most known for preventing conversion of testosterone, the major androgen sex hormone, to the more potent androgen dihydrotestosterone (DHT), in certain androgen-associated disorders.

https://en.wikipedia.org/wiki/5α-Reductase inhibitor
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